CIS doesn't have any heuristics yet. It only flags packers as malware.
If it's packed by Armadillo, it'll flag it as malware. If it's PEShield, it'll flag it. If it's MEW, it'll flag it, if it's Yoda Cryptor/Protector, it'll flag it.
Useless if you ask me but Comodo team disagree with me... oh well.