You are still vulnerable to viruses from the internet, and even cached viruses, so I wouldn't stop it just because running an on-demand scanner. Stopping and starting on access protection will do the function, but you need be sure you are not accessing anything at the time-like checking email, opening files, surfing the net, ... and that can be rather difficult. I run things like MBAM and SAS weekly, but would never turn off Avast! while doing it.