You can most certainly get too much of a good thing and become a slave to security applications, serving them rather than them serving you.
Whilst the top group are fine, I would tend to stick with two MBAM and SAS unless you are after the resident functionality of S&D. SpywareBlaster isn't an anti-spyware but a passive immunisation device.
The sometimes group, I would remove completely as adaware IMHO is a waste of hard disk space and a-squared not far behind. RogueRemover is a specific tool that to all intents and purposed MBAM covers that area well enough.
All the anti-virus and or anti-spyware tools should be secondary to pre-emptive measures, using a more secure browser, firefox with the noscript add-on, reduces the possibility. Running from either a limited user account or running internet facing applications (email, browsers, etc) under something like dropmyrights really cramps the style of malware.
Then you have exercising a high degree of common sense and practicing safe hex.
Then you have your security applications, not forgetting your firewall.
Then you have your back-up and recovery strategy in case even with all of the above, the dark and dirty stuff still hits the fan you have a plan and a fall-back.
