Why couldn't the file/s not be moved to the chest, file in use, etc. ?
If you have XP, vista or Win2k (all 32bit), you could enable a boot time scan. Right click the avast icon, select Start avast! Antivirus, a memory scan will take place followed by the opening of the Simple User Interface, Menu, 'Schedule boot-time scan...' Or see
http://www.digitalred.com/avast-boot-time.php. Don't opt for deletion (you have no options left), always send to the chest and investigate.
What is the malware name, infected file name, where was it found e.g. (C:\windows\system32\infected-file-name.xxx) ?
Check the avast! Log Viewer (right click the avast 'a' icon), Warning section, this contains information on all avast detections. C:\Program Files\Alwil Software\Avast4\ashLogV.exe
- Or check the source file using notepad C:\Program Files\Alwil Software\Avast4\DATA\log\Warning.log and copy and paste the entry.
Having ignore it, the file is still in place, but avast wouldn't/shouldn't let it run, so you need to take further action, like the boot-time scan mentioned above.
As you can see we need information to be able to help when it relates to infected files.
Have you run the MalwareBytes AntiMalware yet ?
If not do so after a boot-time scan and report its findings.