Couple of things to be aware of.
- If items disabled via their own settings, or via msconfig, need to be started (like, you might want to open or use the program affected) it might take a second (or five) longer to respond. But if you're only using it once or twice an hour, then the trade off is worth it. And if you don't find that to be the case, you can always put it back.
-More importantly, it can be fairly easy to get carried away with the "super tweaks" from BlackVipers' site, and end up doing something that prevents your computer from doing what you want (or need) it to do.
I suggest to read the advice on the site fairly carefully, and if you decide to disable or set a service to manual, make yourself aware of what it does, what might depend on it (check "dependencies" under "properties" in "services.msc") and check also what it depends on.
And do one tweak at a time. Have a look at the results over a day or three. Or if you must multi-tweak keep a bit of a detailed log of exactly what you did and when, so you can reverse it if necessary.
It's referred to as "tweaking" and I guess it is, of sorts, but it's really not. All it is is disabling services available in Windows that you don't need to use. Frees up a few more resources, and in some cases may improve security by reducing the number of web-facing applications.