Disabling avast (or excluding the file from scans) to be able to run a suspect file without first having confirmed the detection is bad, is crazy.
That is why I asked the questions to get a better idea of what this is.
You could also check the offending/suspect file at:
VirusTotal - Multi engine on-line virus scanner and
report the findings here the URL in the Address bar of the VT results page. You can't do this with the file securely in the chest, you need to extract it to a temporary (not original) location first, see below.
Create a folder called Suspect in the C:\ drive, e.g. C:\Suspect. Now exclude that folder in the
Standard Shield, Customize, Advanced, Add, type (or copy and paste) C:\Suspect\* That will stop the standard shield scanning any file you put in that folder. You should now be able to export any file in the chest to this folder and upload it to VirusTotal without avast alerting.
This is the correct way to go about things as if it is confirmed to be a false positive then the file can be submitted to avast to correct the detection and that helps all avast users who might also have this program.