This is a common location for rootkits and this is I believe being detected on the anti-rootkit scan (8 minutes after boot). The Ignore option also indicates this is on the anti-rootkit scan. Hopefully you allowed it to be sent to avast for analysis ?
You could also check the offending/suspect file at:
VirusTotal - Multi engine on-line virus scanner and
report the findings here the URL in the Address bar of the VT results page.
If you get multiple detections in VT then reboot and when avast alerts on this allow it to deal with it rather than Ignore.
However, as a first step it is better to rename it to say SUS-Cdns.sys that way the file isn't deleted but renamed. So if it is a necessary file you should get error messages saying the file can't be found. If it does happen to be a rootkit then since it was renamed it too wouldn't be found.