I can't with any authority or knowledge, but some files, often used by other security programs or even MS encrypted files are password protected by their own respective programs, and some might use an unknown compression technique.
Generally if you look at the name and path of a file that's unable to be scanned, it will reveal enough about why to reassure. (That's usually my experience. Part of the OS, or Spybot, or similar.)
I have noticed that sometimes a file that Avast can't scan certain other scanners sometimes can (or claim to scan them); make what you will of that.