No single AV will detect or prevent all malware from getting on a system. That is why you should use other security scanners periodically. Sometimes it's a persistent browser-hijacker and usually malware will hide in System Restore. Malwarebytes, SuperAntiSpyware, and A-squared are what I use as scanners every two weeks or so. I would use a 3rd party browser instead of IE, because most malware is targeting IE. You might also look into learning about and using, Sandboxie, Returnil and Disk-Imaging.