Ad-Aware: not good anymore...
Comodo Firewall: from time to time, issues with avast. For me, it's not a stable firewall or, at least, does not work well with avast (from time to time).
PC Tools Spyware (no AV): ok, but I think it does not improve avast detection significantly.
Prevx: hmmm... won't opinion. I only have tested a long time ago.
Immunet Protect: don't know.
Anyway, your system seems overloaded with security programs. I won't be surprised of hangs and freezes, and "driving me nuts" issues. I think your protection balance is not good, I mean, too much.