Since the file/program is familiar, which I presume has been on the system for some time and the detection is generic, it should be further investigated. So you should have left the file in the chest where it can do no harm anyway, see #### below. Never rush to delete as you have zero options left, so what is suggested below may be a moot point if you haven't got or can't obtain a copy of the file.
- The avast Win32:Malware-gen is generic signature (the -gen at the end of the malware name), so that is trying to catch multiple variants of the same type of malware and is a fine balance between detecting a new variant and detecting something valid as infected.
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You could also check the offending/suspect file at:
VirusTotal - Multi engine on-line virus scanner and
report the findings here the URL in the Address bar of the VT results page. You can't do this with the file securely in the chest, you need to extract it to a temporary (not original) location first, see below.
Create a folder called Suspect in the C:\ drive, e.g. C:\Suspect. Now exclude that folder in the
Standard Shield, Customize, Advanced, Add, type (or copy and paste) C:\Suspect\* That will stop the standard shield scanning any file you put in that folder. You should now be able to export any file in the chest to this folder and upload it to VirusTotal without avast alerting.