That is exactly what you need to do uninstall ZA completely, reboot and do a custom install excluding the AV element.
Resident AVs install low level drivers to hook files to be able to scan them, this can cause conflict, which at worst can lock up your system or worse still if it happens at boot. So if avast detects this it can disable its processes to avoid possible serious conflict.
If this is ZA Pro you may be in for more joys of ZA as its Privacy function can also conflict with the Web Shield.