avast doesn't mess with anything, it simply scans and alerts to infection and I presume that you don't get an avast alert ?
If there is any apparent 'messing' as you say, it is likely to be conflict but not with Outpost, but a possible conflict between another security application and avast. Two security applications (AVs) can lock files whilst they are scanned and that can be the same as two dogs fighting over a bone, conflict.
Have (or did) you another Anti-Virus installed in this system, if so what was it and how did you get rid of it ?
What other security based software do you have installed and running, anti-spyware, etc. ?