When does this happen ?
About the "usigetskin failed" issue, if the avast! repair does not solve it, search for the location of REGSVR32.EXE and modify the run command to adjust:
You will have to register ACTSKIN4.OCX
Follow the instructions:
Select START -> RUN...
Enter the following command:
If you have Windows XP/Vista:
C:\WINDOWS\SYSTEM32\REGSVR32.EXE ACTSKIN4.OCX
If you have Windows XP/Vista x64:
"C:\WINDOWS\SysWOW64\REGSVR32.EXE" ACTSKIN4.OCX
Press OK (or Enter).
A message saying that the file was successfully registered should appear...
For some reason, ActiveSkin (the 3rd party library avast uses for skinning) does not seem to be working on your system. As a workaround, we may disable skinning in avast - that should solve the problem. Program Settings, Common, and uncheck any option with skins mentioned (see image, avast-no-skin).
If you are unable to access the above you can do this manually. To do that, open the file using notepad <avast4>\data\avast4.ini, look up the [UserInterface] section, and add the following entry: StartWithSkin=0 - Save the changes, the avast self-defence module will ask if it is OK answer Yes.
Edit: re-read the question and hopefully the Run command can be accessed by keyboard shortcut 'Windows key'+'R' together.