Any "problem" might depend on what version of PowerDVD you've got. Mine's relatively old (7.0.something), and I've got this file in the program's config sub-folder but avast has never complained about it.
Intel Atom D2700, 2 gig RAM, Win 7 x64 SP1 & IE-11, Firefox 48.0.2
(default). 320 gig HD, 15Mb DSL, Win firewall, Avast 12.3.2280 free, SpywareBlaster, MBAM Prem., Crypto-Prevent