I honestly can't tell, avast doesn't make my boot times longer; CIS that I don't use atm did, a bit, but not dramatically. You're talking about 5 minutes, that's a lot, an awful lot, must be something else going wrong on your system, conflicts between drivers, only you can troubleshoot that...take a look at your settings in Def+ and see the logs too...
Also, you can check what's up in your Windows events: boot times are logged there...
see precisely there:
event viewer: >>>> applications and service logs >>>>Microsoft >>>> Windows >>>> diagnostics-performance >>>> operational