Do you have (or are able to get) physical access to the laptop, or would you need to relay the instructions?
If the latter, given your friends' indicated lack of AV awareness, it is going to be difficult.
Some of us would maybe be able to talk him through what do do/good ideas, but relaying it?
I'd be looking at the idea of a BART disk. DrWeb, Avira, and Kaspersky (and a few others) have the files available for free download. He'd need a clean computer with a disk burner to make the disk.