The HKLM\...\NoActiveDesktopChanges registry key above determines
whether or not the users of the machine have the ability to change
their active desktop configuration. There are a large number of
trojans and malware that change that registry entry to "1" in order to
prevent users from removing the displayed content within the active
desktop. You can also set this to 1 to prevent users from changing
their wallpaper, for instance. It is not necessarily an indication
that you are compromised, but by default users are allowed to change
their active desktop settings. The Malwarebytes program flagged the
registry entry because it is more often than not an indication that
malware may be present. If you are comfortable with the appearance
and functioning of your Windows desktop, and don't plan on allowing
other users to change the desktop settings, then leave the registry
entry set to 1, otherwise set it to zero or allow Malwarebytes to do
it for you.
and DavidR is spot on.....