I really appreciate the diversity of opinions guys. As with most things, I think it just comes down to personal preference.
For my own experiences, I have found infections on PC's using avast 4.8 in safe mode that 4.8 didn't pick up in a standard system scan. I prefer having the access to my system a safe mode scan provides if something is found, as opposed to what provided during a boot-level scan.
Either way, I will continue to recommend, and help install Avast! for friends and family who are looking for good, no worries AV protections.
I think I will try something else for awhile, and if I get burned, I'll come limping back with my tail between my legs.
