Sorry mkis,
What I mean by "right out of the gate" is that I downloaded the program and updated it, but the built in security center that comes with windows vista said it couldn't recognize the new anti-virus. THAT problem seems to have corrected itself after a shut-down/restart. If the security center doesn't recognize your Av software, it will "red Shield" you until your turn it off or correct. So for that at least, problem now solved.
I can use Avast! 5.0.462 without any problems if I just run it in regular use mode. What happens now is that when I put my PC into Safe Mode, I cannot run Avast! at all. It gives me the error comment I posted above. I can run all my other stuff fine, like malwarebytes, Ccleaner, etc. Avast! is my only real-time AV program, and with 4.8 free home edition, I could run it in Safe Mode.
I was considering just uninstalling it and reinstalling it, but that's kind of a pain in the butt. Would like to resolve this issue without having to resort to that.
I will check out your links.
Thank You,
Philo