kalirion, seems that the full virus definitions are being downloaded in some 4.8 systems. I'm not sure.
I think version 5 has quite some improvements.
But look, there is always the problem of the boot: antivirus and firewall are "problematic" applications during the logon... they use quite some resources. Do you have many programs being auto executed in logon?
I just tried a manual update for the 2nd time, and it downloaded the standard small size update, so I guess its all good.
As far as the startup programs, aside from AV / firewall I have:
Nvidia stuff
Creative Sound Blaster stuff (using SB Live card after onboard sound died)
Logitech stuff (for mouse and webcam)
Microsoft Intellitype Pro
rthdcpl.exe (realtech hd sound driver I should probably disable since I don't use realtech hd sound)
All other stuff like Quicktime junk I have disabled.
For services aside AV, and Firewall related ones I have (after checking "Hide All Microsoft Services"):
InstallDriver Table Manger
Windows Cardspace
Process Monitor
nHancer support
Nvidia Display Driver Service
Microsoft Office Diagnostic Service
Office Source Engine