I agree with all of the above. You have too many conflicting software.
Delete ASC Pro, which depending on what version you have also has ZA AV in it. This will conflict with Avast. In addition ASC does a lot of system restores. I would replace it with CCleaner
http://www.piriform.com/ccleaner/builds, which is light on your system and is more efficient.
Delete Spybot as many on the forum have reported issues with it, and as mentioned in earlier posts replace it with
free MBAM, which is more efficient and light on your system
http://www.malwarebytes.org/mbam.php.
Disabling your conflicting software will not resolve your problem since you still have the registries on your machine; you need to delete it.
Make sure you have the lastest build of Avast (5.0.594) and are current with the virus definition updates.
Please report back.