My luck lasted about a month, when I first installed Avast! on top of the McAfee that came bundled with my pc.
Seemed logical, turning McAfee off, keeping it for on-demand purposes. But logic is only sound when you see the whole picture, which I did not.
Hindsight came in the form of many BSOD's.
I wasn't unlucky enough to get a reboot-loop or anything that nasty, but still unpleasant and potentially damaging.
Save yourself the headache. Layer different forums of protection, not the same.