I tried CIS 5. Is good, but its false positives are many. Its sandbox is too intrusive, they need to add more trusted signatures to their whitelist and improved it. Really It caused me headache, i chose NOT sandbox again, and it continued sandboxing tha same aplication. The only thing that make its protection good is the Defense+.
avast! have better virus database than Comodo.
Edit: I still prefer avast!