First rule of infection: Do Not Panic
Shouting wont get him here quicker, he is likely in bed by now.
If even safe mode is unworkable, I would say the next step is a rescue disc, most often Dr. Web is recommended.
But just to be certain, wait for essexboy's suggested course of action. The worse the infection, the more damage attempting to clean it can cause, you do not want to go from what you have (a nasty infection) to something worse (a brick).