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No, i play the game in another computer which i didn't install comodo. I'll try your suggestion. But where i must add to exclusion? Just in setting menu?
It rather depends on what is stopping/blocking or alerting on gameguard.
Since it effectively works like a rootkit hidden from normal APIs it could be the anti-rootkit scan 8 minutes after boot if this is an avast alert ?
If so I can't recall if there is an easy way to add an exclusion to that scan, but there may well be something in the alert itself to a) Ignore and b) Do not tell me about these files in the future (need to open the Advanced section). See example image, which is from avast 5.x so I don't know if this is in the avast 6.x anti-rootkit alert.
You could also check the Behavior Shield report file for any entry related to gameguard, C:\Documents and Settings\All Users\Application Data\AVAST Software\Avast\report\BehaviorShield.txt for XP. Or C:\ProgramData\AVAST Software\Avast\report\BehaviorShield.txt for Vista, Win7. The above locations are if a clean install of avast6, other wise it will be Alwil Software\Avast5\report, etc. etc.