I would try an Avast Repair first:
- Go to Control Panel > Add/Remove programs > Avast Antivirus.
- Scroll down and choose Repair function in the pop-up window.
- Reboot.
Since you did an upgrade from 5.0 to 6.0, if the Avast Repair fails to fix your problem, you may want to consider an uninstall/clean install using the Avast Uninstaller Tool
http://files.avast.com/files/eng/aswclear6.exe and remove ALL versions/products of Avast on your machine in Safe Mode prior to reinstalling, reboot, then install.
Having MBAM and Avast on your machine will create no conflicts. You have put them into exclusions, so there is no problem there.
Having your machine go to sleep should not be an issue. However do you clean your machine out after surfing with something like CCleaner? This may speed thing up for you. There is a
Slim version available as well at
http://www.piriform.com/ccleaner/builds – 4th option down. It removes unused files (cache, temporary Internet files, etc.) from your system, allowing Windows to run faster and freeing up valuable hard disk space. It also cleans traces of your online activities such as your Internet history.
Have you done any "housecleaning" to remove dust in the CPU area of the fan? Is the CPU well ventilated, especially leaving it on long hours?
Let us know how the Repair works, and if you need to do the uninstall/reinstall resolves your problem. Thank you.