Thank you for your replies.
@artemis I have disabled avast's autosandbox, but those two files still appear in Sandboxie.
@Dieselman Actually, the main purpose of Sandboxie is to protect your system from changes, not just your browser. Many people run an incredible assortment of programs that reach out to the internet in Sandboxie. Whether one needs to sandbox a word document may be debatable; however, until just recently, I was able to open a downloaded Word document from within Sandboxie and the document would open in a Sandboxed version of Word.
I am aware that Sandboxie of the differences in versions.