The exact problems are:
When i start the computer it starts normally, but after I trying to open something from or copy to the 300 GB hard drive (simply click on its icon from the "My computer", the computer immediately crashes (unresponding). Also when i want to open the Recycle bin, this happens (maybe the recycle bin opens the 300 GB hard drive too). And sometimes crashes suddenly.
BUT when I turn off one of the parmanent protections, and try to use the 300 GB hard drive, and re-enable protection, it works correctly until the next computer restart.
The another problem is that when avast found a threat on the flash drive, the browsers (IE and Firefox) become very slow until the next computer restart, even the flash drive was removed.