Yes and no.
First, I'm a bit surprised about the alert. The folders you are talking about - are avast! virus definitions. Every virus definition is downloaded and extracted into a new folder; this folder contains a number of files, including about 15 DLLs. The names or numbers of the DLLs may change any time, a virus definition folder created tomorrow might look different that the one created today. Yes, aswRep.dll is new, it was introduced just recently... but does Comodo really keep a list of names of our virus definition files and whitelists them, based on the names? Or have you created a set of rules yourself?
As for the meaning - it's not directly related to WebRep, at least not the one you have, or don't have, installed on your machine. The file will soon be providing additional "cloud" features for the scanning engine, for example by giving it access to some statistics gathered from WebRep. (Don't worry, there won't be any detection based on whether the particular site is red or green in WebRep, that value won't be used for anything - but there are other values that actually might be useful as an auxiliary info for some heuristic detections).
Yes, it also means that the avast! service may actually start making some network connections occasionally.