I doubt your problem is the same as Chrismoskal as he has a rogue security application on his system, "xp antivirus 2012."
Your problem or rather not a problem stems from your having run an avast scan and avast (unlike other AVs) tells you if a file hasn't been scanned, rather leave you none the wiser if it didn't report it.
Files that can't be scanned are just that, not an indication they are suspicious/infected, just unable to be scanned.
Many programs (usually security based ones) password protect their files for legitimate reasons such as AdAware and Spybot Search & Destroy, there are others (and avast doesn't know the password or have any way of using it even if it did know it).
When you run scans with the above programs and you delete harmful entries that they detect, a copy is kept (in quarantine/restore/backup) in case you need to reverse what you did. These are usually password protected, you should do some housekeeping and delete old backup/recovery/quarantine entries (older than two weeks or so), this will reduce the numbers of files that can't be scanned.
By examining 1) the reason given by avast! for not being able to scan the files, 2) the location of the files, you can get an idea of what program they relate to. You may need to expand the column headings to see all the text.
If you can give some examples of those file names, the locations and reason given why it can't be scanned might help us further ?
Essentially there is no confirmed infection, etc. so there is no need to take any action and the 'Apply' button would be greyed out.