Same here:
[Move to Chest] and [Delete] don't work as the file is protected by Avast against tampering.
The popup won't go away until you make it [Block] the file.
Excluding [R][W][X] [C:\Program Files\Alwil Software\Avast5\defs\*] from the File System Shield scanning coverage shuts it up, but ignoring it doesn't seem to be the best idea.
Manual scan of [C:\Program Files\COMODO\] turns out clean.
Manual scan of [C:\Program Files\Alwil Software\Avast5\defs\] finds the "infection".
It's as if the VPS 120203-0 update contains a malware signature/sample which in itself is regarded a threat by Avast.
I hope VPS 120203-1/120204-0 will address this and be released soon.
Just now, while it wasn't excluded from File System Shield scanning, I couldn't open Firefox. Only the [firefox.exe] processes would start without showing the program window. I could open Firefox once I selected and applied [Block] in the popup.