After you download OA and do everything that I suggested, OA require two (2) reboots. Make sure you put your exclusions in prior to doing the reboots. There is a new version of OA out now 5.5.0.1616, which should bring you to the updated version when it automatically does the update after the reboots, or you can manually do an update if you have the Free version. Reboot again twice if you get the newer version.
When installing a newer version of software, including MS/Windows Updates, I usually put OA into Learning Mode. As mentioned earlier, each software like Flash, has it's own Uninstaller. It is best to uninstall ALL versions of Flash prior to installing the newest version and reboot after each uninstall and install -- this is actually very easy and quick to do. You can save the Flash Uninstaller tool on your desktop since they change it so often (or if you need the memory put it on a stick). Then install one version of Flash (IE), and if needed a plug in (e.g. Firefox, etc.) one at a time with a reboot in between while OA is in Learning Mode.
Once done, take a look at OA Programs > unclick "Hide Trusted" to see that everything on the left column is check off in green. If it is not in green (meaning allowed), then right click it and a pop-up will appear and you can "Allow it" if it was a new software you just installed. Once done, click "Hide Trusted" again to minimize your list in OA. The go to the bottom of your toolbars, right click on OA, and then left click on Learning Mode to take it out of Learning Mode and put it into the Mode you want (Standard or Advanced).
Let us know if you have any questions.
