AnalogX Script Defender will intercept any request to execute the most common scripting types used in virus attacks, such as Visual Basic Scripting (.VBS), Java Script (.JS), etc and can even be configured to intercept new script extensions as needed! It's very simple to use and helps to ensure that you do not inadvertently run a script no matter what email program you use, or even if you get it via another method.
In home version you could add this line:
WS?,VBS,VBE,JS,JSE,HTA,WSF,WSH,SHS,SHB
at Scanner (Advanced) section of Resident task options...
Although it is not the same: Script Blocker (as Script Defender) will deny running of the script. The line above says to the Resident task to 'scan' the script file.
If you need more protection, think about the avast! Pro version