Updated program on 6-27-12 and immediately no connection to the internet. I got the same error as well, Avast will not protect news/mail, Error 10045. Could not connect to the web, searched at work and found this suggestion, on left side of UI, select Firewall, then select Expert setting and select auto decide for firewall mode and click on the box that says use fast checksums. Seems to be working at this time.
AIS v 7.0.1451
Dell Inspiton 570, windows 7 64 bit, sp1, MBAM v 1.61.0.1400