It seems that avast! can now directly flag certain files that only have malicious reputation without placing them in the Auto Sandbox for further evaluation.
Yes, that's true.
It's not necessarily about reputation though (a reputation alone wouldn't be enough for a full detection, it has to be backed up by some analysis).
It's more about using some powerful hardware (the last image
here, in particular - pity you can't see the nice "cooling tower") to perform a clever analysis of incoming malware samples, and then connecting it to the FileRep infrastructure to distribute the new detections at the maximum possible speed.