I wouldn't worry, just un-tick it (ignore) as its a temporary file used during Avast updates and is deleted by avast afterwards. CCleaner is just trying to remove its reference in the registry, like many "same name" temporary files it will return and so its normal for CCleaner to think its no longer needed.
I've had Avast.Setup showing in CCleaner occasionally for the last year or so.
Theres no problems in deleting it either, it will just return.