I have always been very cautious (read anti) about programs like this, but for testing purposes which you are obviously doing, I would recommend a system image before running anything like this.
6 hours is an eternity compared to probably less than 30 minutes to restore the system image.
Yes I do use registry cleaners, but I monitor what it is going to do (I don't know if this cleaner goes into this amount of detail) and I select what is to be cleaned. Even then it will backup these registry changes so they can be restored.
Looks like this cleaner needs to be able to restore any changes that it makes.