rootkit HKU\S-1-5-21

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I have a recurring problem.  Found a few glitches in my computer so I ran Malwarebytes and identified 2 threats:  HKU\S-1-5-21-2645729826-27...66-2386374640-1000_Classes, both with the same number.  I removed the threats to quarantine, then deleted them.  A couple hours later the exact same threat is back.   I have removed 4 time so far and it returns every time.   Can anyone help with this???   

[Pondus]

Since this is detected by Malwarebytes i suggest Malwarebytes forum

Malware Removal for Mac  >>  https://forums.malwarebytes.com/forum/165-malware-removal-for-mac/

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Malwarebytes doesn't seem to be working.  Can anyone assist with how to tackle this problem

[Eddy]

The malwarebytes webboard is working.

[Michael (alan1998)]

I think he means the program... (Which isn't a good thing really...)

Have you tried launching MBAM as Chameleon mode?

https://www.malwarebytes.com/chameleon/

[Pondus]

I think he means the program... (Which isn't a good thing really...)

Have you tried launching MBAM as Chameleon mode?

https://www.malwarebytes.com/chameleon/

He has posted in MBAM forum