You could have them disable the self-defence module, Program Settings, Troubleshooting, 'Disable avast! self-defence module.' That however, might seem daunting to some.
Since avast isn't running when in safe mode I guess you could try from there, but again you would have to get them to boot into safe mode which would mess with their desktop icons when back in normal mode.
So I think that it would be the best to have them uninstall as there is no way you might know if they have installed whatever version they have in the default installation folder.
Thanks for the insight into the silent install.