What is the infected file name, and the malware name e.g. (C:\windows\system32\infected-file-name.xxx, malware name) ?
Check the avast! Log Viewer (right click the avast 'a' icon), Warning section, this contains information on all avast detections.
You may have an undetected downloader or browser hijack on your system.
If you haven't already got this software (freeware), download, install, update and run it, preferably in safe mode and report the findings (it should product a log file).
SUPERantispyware On-Demand only in free version.