I don't know about the first issue. I don't know what or where you're relaying to. It should be working fine if you just use DNS to route email...
I think I have a fix for the unresponsive avast icon though.
In your ADNM console, right-click the, "Computer Catalog" and click Properties. (This will modify all other groups that you may have created).
Then, click on the "Local Scanners" section (see attached picture). You probably have the two settings set to "disable" which prevents you from clicking on the avast icon and changing the properties.
I have mine set on "ask for password." So, I can click on the icon, put the password in, and then access the settings.
I noticed that your ADNM console is pretty out of date too.
Go to control panel, Add/Remove programs, and click on the "Avast Management Tools" and click change/remove button. Then, look for the update button, and continue the process.