HIPS can't be helpful in those situations?
HIPS can be helpful in those situations
IF the user selects the correct answer to the prompt. That IF is the main point of failure here. If you answer allow to all, it won't help you. If you answer deny to all, you'll kill your operating system sooner or later. And if you can choose a correct answer, you presumably don't need any HIPS at all.

So, IMNSHO better than HIPS are methods like using a limited user account with software restriction policies where you only allow users to execute stuff in %WINDIR% and %ProgramFiles% directories to which they lack write permissions, so they cannot save any files there, and hence cannot execute any malware they've downloaded, sandboxing browsers etc. etc. Those require almost no user intervention so this reduces the main point of failure (the user factor) to a great extent.