So, I read up a little on this idea. I answer no.
It seems a very secure idea. But it also seems like actually placing my security system ahead of my OS in priority, is that even a good idea? I mean, noob I may be, but that seems like screwed up priorities there, taking security a single step too far.
If some full-on Cyber War broke out I might be happy to have a system idea like CIS's, like hiding in a bunker when bombs are falling. But unless Avast! could develop the greatest whitelist ever known (and keep it that way, indefinitely), I will continue to take my AV as-is.