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It is normally associated with the SIS chipset USB driver. I haven't heardof any malware that uses this filename but you never know. If yourmotherboard uses the SIS chipset I would allow it.
I don't know why it would come on/alert after being on-line for an hour. If it is the same avast alert example image that I posted as that is the anti-rootkit scan and only runs at certain times (this isn't one of them) ?