I use a HTC Desire with a rooted stock ROM.
I updated the Avast software via the in-app update function, which mentioned there would be a new version. As my Desire is only rooted and not 'S-Off', the NAND option did not work so I used the UPDATE.zip option and flashing this via recovery, as suggested by the program.
After applying this update, my phone did not boot anymore and was restarting itself time after time. The first white-green HTC screen appeared, but before the next one could appear (with the black HTC text on it) the phone rebooted already.