Personally I can't see why RAM needs to be defragged, it doesn't suffer the same issues as a fixed hard disk when heavily fragmented. Certainly not with modern systems and RAM.
This is the same as SSD Solid State Disks in a way, which they don't believe need to be defragged; not only that but there is supposed to be a life to SSDs and defrags potentially shorten that life.
How to defrag RAM, reboot, done.
For me I really see no need to even contemplate defragging RAM as all locations are addressed in RAM and it isn't as if like the hard disk it has to spin to multiple locations for the data, which is the true problem with HDD fragmentation.