Yes it takes *cough* some time for avast to respond but eventually they will.
I've said it in other threads, tools like CleanUp don't do anything you can't do already natively with the OS.
It can help doing some things faster, but that is all.
If you (or anyone else) really want to use such a tool, I recommend CCleaner (pretty good and free).
As every system/user is different, a simple batch file that removes what the user wants will work real nice.