I don't know if this is specific to 6.0.1044 because I have not tried it with earlier versions.
XP SP3 - nVidia 7600 - dual monitors
When I switch to SafeZone the video output signal apparently drops on both monitors so that the screens appear dull grey and stay that way until Windows is restarted.
Also, both the mouse pointer and/or the flashing insertion point within the text box become invisible (compare attached images and note that screen capture does not show the dullness).
The screens flash at full brightness briefly when I switch back and forth between SZ and normal but a restart is the only cure.